Kristof Wing

Impact of Rare and Common Genetic Variation on Cell Type-Specific Gene Expression

Single-cell eQTL mapping in 5.4 million PBMCs from 1,925 individuals with matched WGS finds common-variant eQTLs for 83% and rare-variant signals for 47% of 21,404 genes.

Tandem repeat variation shapes immune cell type-specific gene expression

The paper identifies immune cell type-specific gene expression regulated by tandem repeats using multi-omics data from large cohorts.

The impact of sex on the immune system explored at the single-cell level

The paper examines sex differences in the immune system at the single-cell level, identifying sex-biased genes and eQTLs linked to autoimmune diseases.

Deep Learning-based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell and Organelle Morphology

The paper uses AI to identify genes associated with intraocular pressure by analyzing morphological changes in trabecular meshwork cells after gene knockouts.

High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma

This study uses gene knockouts and single-cell RNA sequencing to identify genetic networks contributing to elevated intraocular pressure in glaucoma.

Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing

This study compares the performance of BGI and Illumina sequencing technologies for single-cell RNA-sequencing, finding that BGI outperforms Illumina in cell and gene detection but similar in gRNA detection.

Efficacy and dynamics of self-targeting CRISPR/Cas constructs for gene editing in the retina.

This study develops a self-destructing CRISPR/Cas system for retinal gene editing, showing reduced SpCas9 mRNA and improved safety without compromising on-target efficiency.