ImmunologyPLoS PathogensPeer-reviewed
An IL-1, IL-17, and IL-22 cytokine circuit controls vulvovaginal candidiasis independently of estrogen
Bianca M. Coleman, Melissa Erin Cook, Md. Robin Khan…·Sarah L. Gaffen
1 citation
Author
Sarah L. Gaffen
University of PittsburghORCID 0000-0001-8511-2041Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 36 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- ImmunologyNature CommunicationsPeer-reviewed
An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans
Pallavi Kakade, Juan F. Burgueño, Shabnam Sircaik…·Richard J. Bennett
This study identifies an IL-17-DUOX2 axis that regulates C. albicans colonization and filamentation in the gut through interactions with candidalysin toxin.
2 citations - MicrobiologybioRxivPreprint
The IL-1 Family Controls Acute Mucosal Fungal Infection and Mucosal-Systemic Dissemination.
James S. Griffiths, Alexander Kempf, Robert J. Pickering…·Julian R. Naglik
This study shows the IL-1 family is essential for mucosal defense against Candida albicans, preventing infection and dissemination, but its absence in neutropenic conditions leads to fatal systemic infection.
DOI 10.64898/2026.04.10.717440 - ImmunologyNature CommunicationsPeer-reviewed
Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance
Nicolas Millet, Jinendiran Sekar, Norma V. Solis…·Marc Swidergall
This study shows that fungal-induced immunosurveillance remodels the oral mucosal barrier via a non-canonical IL-22 receptor complex, enhancing resistance to Candida albicans colonization.
6 citationstop 1% - MicrobiologybioRxivPreprint
N6-methyladenosine (m6A) RNA modification restrains antifungal immunity and is a therapeutic target in oral candidiasis
Nicole O. Ponde, Melissa Erin Cook, Isha Mehta…·Sarah L. Gaffen
This study shows that m6A RNA modification suppresses antifungal immunity in oral epithelial cells and that inhibiting the m6A pathway enhances antimicrobial peptide expression, reducing fungal burden in candidiasis.