Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury
Sayyed Farshid Moussavi-Harami, Simon J. Cleary, Mélia Magnen, Yurim Seo, Catharina Conrad, Bevin C. English, Longhui Qiu, Kristin M. Wang, Clare L. Abram, Clifford A. Lowell, Mark R. Looney
This study shows that loss of neutrophil Shp1 causes severe lung injury and death in mice, and that activating Shp1 can reduce inflammation and lung damage.
Journal of Clinical Investigation · Oct 1, 2024Peer-reviewedImmunology