Rusty L. Montgomery

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

A stabilized miR-29 mimic, MRG-229, shows efficacy at lower doses and good safety in preclinical models, supporting its development for pulmonary fibrosis.

The paper identifies lncMYH7b as a regulatory long noncoding RNA in the human heart that influences the ratio of β-MyHC to α-MyHC through TEAD1/TEAD3 regulation, independent of miR-499.