Gail McConnell

A method for correcting background non-uniformity while preserving specimen-level information in Fourier ptychographic microscopy images

This paper introduces a background correction method for Fourier ptychographic microscopy images that preserves specimen information and improves quantitative analysis.

Cross-scale Imaging of Live Botanical Specimens using Fourier Ptychographic Microscopy

This paper applies Fourier ptychographic microscopy to label-free imaging of large botanical specimens, achieving high-resolution imaging over a large field of view.

Multimodal imaging reveals surface degradation of voice prosthesis implants resulting from colonisation by polymicrobial biofilms

The paper uses multimodal imaging to show that polymicrobial biofilms degrade silicone voice prosthesis implants by invading the device and releasing silicone particles.

Open Fourier Ptychographic Microscopy (OpenFPM)

OpenFPM provides an open-source, low-cost Fourier ptychographic microscopy platform for high-resolution biomedical imaging.

Human buccal epithelial microplicae maintain a characteristic wavelength despite variable network topology

CASC: Content-Aware Compaction of Sparse Microscopy Images

CASC reduces microscopy image file sizes by removing spatial redundancy while preserving object-level biological structures.

Analysis of Biofilm Complexity in 3D (ABC3D): An open-source framework for quantitative fractal, textural, and statistical analysis of colony biofilm morphology in three dimensions

ABC3D quantifies 3D biofilm morphology using fractal, textural, and statistical features, showing nutrient availability and cell shape influence biofilm structure in E. coli.

A rapid, low-cost approach to solid immersion lens fabrication for enhanced resolution in optical microscopy

This paper presents a low-cost, rapid method to fabricate solid immersion lenses (SILs) that enhance optical microscope resolution, achieving performance comparable to commercial glass SILs at a fraction of the cost.

Low-Cost 3D Printed Optics for Super-Resolution Multifocal Structured Illumination Microscopy

This paper develops low-cost 3D printed lenslet arrays for super-resolution microscopy, achieving resolution comparable to commercial optics.

Revealing the Ultrastructure of Live Candida albicans using Stimulated Emission Depletion Microscopy

This study uses STED microscopy to improve resolution of Candida albicans ultrastructure, showing better performance than confocal microscopy for tracking sub-cellular components over time.

A large 3D-printed integrated lens-biprism element enhances contrast in transmission stereomicroscopy

The paper introduces a 3D-printed lens-biprism element that improves image contrast in stereomicroscopy by enhancing illumination uniformity.

Extracting biological structure and heterogeneity from the nano to the macro scale

This paper introduces SQUASSH, a convolutional neural network that fits structural models to fluorescence microscopy data to quantify variability across biological scales.

A simple silicone elastomer colonisation model highlights complexities of Candida albicans and Staphylococcus aureus interactions in biofilm formation.

This study develops a silicone elastomer colonization model to investigate C. albicans and S. aureus biofilm formation on medical devices, revealing morphological differences based on C. albicans cell morphotypes.

Assessing the role of collagen to improve understanding of disease pathophysiology in patients with acute recurrent tonsillitis

This study examines collagen levels in tonsils of patients with acute recurrent tonsillitis and obstructive sleep apnoea to better understand disease pathophysiology.

PerfectlyAverage: a classical open-source software method to determine the optimal averaging parameters in laser scanning fluorescence microscopy

PerfectlyAverage determines optimal averaging parameters in laser scanning fluorescence microscopy by analyzing SNR, photobleaching, and PSD to reduce acquisition time.

Oxygen Microenvironments in E. coli Biofilm Nutrient Transport Channels: Insights from Complementary Sensing Approaches

This study quantifies oxygen gradients in E. coli biofilm transport channels using three sensing methods, revealing anoxic conditions that challenge previous assumptions about channel openness.

A fully 3D-printed optical microscope for low-cost histological imaging

The paper describes a low-cost 3D-printed optical microscope capable of sub-cellular resolution for histological imaging, using affordable components and open design for replication.

Obtaining super-resolved images at the mesoscale through Super-Resolution Radial Fluctuations

This paper demonstrates a method to achieve high-resolution imaging over a large field of view using SRRF and Mesolens, achieving 446.3 nm resolution with minimal error.

A Novel 3D Imaging Approach for Quantification of GLUT4 Levels across the Intact Myocardium

The paper introduces a 3D optical mesoscopy method to quantify GLUT4 levels in intact mouse hearts and shows gender-dependent expression changes with high fat diet.

FISHtoFigure: An easy-to-use tool for rapid, multi-target partitioning and analysis of sub-cellular mRNA transcripts in smFISH data

FISHtoFigure is a software tool for analysing smFISH data, enabling automated spatial analysis of mRNA expression without requiring bioinformatics expertise.

Label2label: Training a neural network to selectively restore cellular structures in fluorescence microscopy

This paper introduces a neural network method to restore fluorescence microscopy images by reducing background signals from non-specific labeling.

Application of the Mesolens for sub-cellular resolution imaging of intact larval and whole adult Drosophila

The paper demonstrates the use of the Mesolens to image sub-cellular details in intact Drosophila larvae and adults without dissection.

A 340/380 nm Light Emitting Diode Illuminator For Fura-2 AM Ratiometric Ca2+ Imaging Of Live Cells With Better Than 5 nM Precision

This paper introduces a 340/380 nm LED illuminator for Fura-2 ratiometric Ca2+ imaging, achieving better than 5 nM precision and faster acquisition speeds for detecting Ca2+ events in live cells.