Nicholas John Maragakis

This paper develops a human iPSC-derived microfluidic platform to model corticospinal tract connectivity and pathology for neurodegenerative disease research.

This study examines 15q11.2 deletion effects on neuronal development and function using iPSC-derived neurons, finding structural and functional impairments in network connectivity and maturation.

The paper analyzes phase-amplitude coupling in human 2D neural cultures to show that network-level interactions, not single neurons, drive coupling, suggesting PAC is a fundamental property of neural networks.

This paper shows edaravone protects mRNA-induced motor neurons from neurotoxicity by activating the GDNF/RET signaling pathway and can replace neurotrophic factors for neuron survival.

This study shows that Cx43 hemichannels in astrocytes contribute to ALS progression and that blocking them can protect neurons and improve survival in ALS models.

This study shows that Cyfip1 is critical for maintaining the adult subventricular zone niche by regulating B1 cell proliferation and adherens junction proteins.

This paper develops a co-culture method for human iPSC-derived astrocytes and motor neurons in MEA systems, showing bidirectional maturation effects.