Author

Ilaria Gritti

Broad InstituteORCID 0000-0002-7313-0450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

Adam Samuel SperlingiD· 1 shared Alexandra PopaiD· 1 shared Andrew E. H. EliaiD· 1 shared Cameron Schluter· 1 shared Carmen Da Silva· 1 shared Cristina Rosa FerroneiD· 1 shared Cyril H. BenesiD· 1 shared Cyrus Jin· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Adam Samuel SperlingORCID

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2 papers

Recent·Most cited

Distinct Proteasomal Pathways Drive Oncogenic PPM1D Activation

Ni Yan, Deumaya Shrestha, Cameron Schluter, Cyrus Jin, Edward Wang, Carmen Da Silva, Ilaria Gritti, Nikolaos Tsopoulidis, Ruxin Yang, Adam Samuel Sperling, Jonathan M. Tsai, Andrew E. H. Elia, Eric S. Fischer, Mikolaj Michal Slabicki, Eugene Oh, Peter Grant Miller

This study shows that truncating mutations in PPM1D shift its degradation pathway from ubiquitin-independent to UBR5-mediated, leading to increased PPM1D levels and oncogenic effects.

bioRxiv · Jun 9, 2026 · PreprintCell Biology

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets

Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qibiao Wu, Yuanli Zhen, Robert Tyler Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, , Nabeel M. Bardeesy

This study creates a biliary tract cancer cell line atlas using multi-omics data to identify molecular subtypes and therapeutic targets.

Cancer Discovery · May 12, 2025Peer-reviewedCancer Biology