PURELIGHT: a quantitative photon-counting framework unifying intensity and lifetime imaging at video rate across detector technologies
Felipe Velasquez Moros, Dorian Amiet, Daria Skwarzyńska, R. Meister, Urvashi Dalvi, Saidong Ma, Peter Rupprecht, Shuting Han, Philipp Bethge, L. Krainer, Giulia Acconcia, Ivan Rech, Fritjof Helmchen, Paul Zbinden, Aiman S. Saab, , Luca Ravotto
PURELIGHT improves photon efficiency and accuracy in fluorescence microscopy by recovering undistorted intensity and lifetime measurements at high count rates across multiple detector technologies.
bioRxiv · Sep 3, 2026 · PreprintNeuroscience