Philipp Bethge

PURELIGHT improves photon efficiency and accuracy in fluorescence microscopy by recovering undistorted intensity and lifetime measurements at high count rates across multiple detector technologies.

aDISCO enables 3D microscopy of large archival FFPE human tissue blocks, revealing subtle pathologies in focal cortical dysplasia through deep-learning analysis.

The paper introduces Pythia, a tool that uses deep learning to predict CRISPR/Cas9 integration and editing outcomes by leveraging non-random DNA repair patterns.

The paper shows that dendrites have nanoscale constrictions that create electrical compartments, altering synaptic integration in neurons.

This paper introduces angioMASH, a method to visualize vascular and cytoarchitectonic features in human brain tissue, revealing layer-specific vascular density and orientation differences in visual areas V1 and V2.

The paper introduces an improved open-source light-sheet microscope, mesoSPIM, with enhanced resolution, throughput, and compatibility with cleared samples.

This study shows that leptomeningeal collaterals regulate reperfusion in ischemic stroke, with poor collaterals leading to hemorrhage and poor outcomes.

The paper shows that dendritic responses in L5 pyramidal neurons during learning correspond to unsigned temporal difference error components, with salience signals aiding task learning.

This study shows that motor cortex neuronal populations encode limb movement differently based on environmental context, with M2 influencing this context-dependent encoding.

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.