Theofanis Karayannis

The paper identifies local inhibitory dynamics in mouse barrel cortex that support temporal integration and functional segregation between barrels and septa during whisker stimulation.

This paper maps α-synuclein pathology and dopaminergic degeneration in mice using multimodal imaging and microscopy, showing spread along the nigrostriatal pathway and microstructural changes.

This study shows that abnormal astrocyte activity during adolescent prefrontal cortex development leads to synaptic loss, interneuron dysfunction, and cognitive deficits.

The paper identifies a distinct hypothalamus-habenula circuit that governs risk preference in economic decision-making.

MortX provides a benchmark dataset for mouse cortex segmentation and registration, enabling domain generalization across postnatal ages.

The paper identifies a developmental switch in information transfer from wS1 to wS2 cortex in mice, showing excitatory connections emerge after the first post-natal week.

The paper develops a human iPSC-derived neural model to study TDP-43 pathology, identifying NPTX2 misregulation as a key factor in ALS/FTLD neurotoxicity.

The paper identifies layer 1 NDNF+ interneurons in mice as key for integrating bilateral sensory information through NMDA receptor-dependent inhibition of layer 2/3 neurons.

This study shows that Prox1 regulates the final specification of VIP interneuron subtypes by controlling Elfn1 function in post-mitotic stages.

The paper investigates how GABAA receptor subtypes and gephyrin post-translational modifications influence layer 2/3 pyramidal neuron responsiveness in mouse barrel cortex during sensory processing.

The paper identifies a developmental transition in VIP+ and SST+ interneurons in the mouse barrel cortex around P14, where their responses to multi-whisker stimuli diverge and their thalamic inputs shift.

SpineS is an open-source software for automatic longitudinal analysis of dendritic spine dynamics with manual intervention, showing high performance on two-photon and confocal imaging datasets.

The paper identifies CCK+ S1-CST neurons as a major cortical input to the spinal dorsal horn and characterizes their synaptic connections and molecular diversity.

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.