Aleksander Szczurek

Nuclear-BRITE reduces background noise in MS2-based live-cell imaging of nuclear RNAs without affecting their abundance or function.

The paper identifies a new SET1B complex and shows SET1/MLL complexes control transcription independently of H3K4me3 by counteracting promoter-proximal termination and supporting transcription burst size.

This study investigates SMCHD1's chromatin interactions and shows LRIF1 and ATPase activity are critical for its selective binding and epigenetic silencing functions.

The paper identifies a CpG island-encoded mechanism where SET1 complexes interact with WDR82 to prevent premature transcription termination, distinguishing genic from non-genic transcription.

This study identifies PRC1's role in Polycomb-mediated gene repression by showing it independently counteracts RNA polymerase II binding and controls transcriptional burst frequency.

The paper shows cohesin disrupts polycomb-dependent chromosomal interactions to regulate gene repression in embryonic stem cells.