Author

Anna Lastuvkova

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:ChIP-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Robert J. KloseiD· 4 shared Aleksander SzczurekiD· 2 shared Amy L. Hughes· 2 shared Anne H. TurberfieldiD· 2 shared Emilia DimitrovaiD· 2 shared Neil P. BlackledgeiD· 2 shared Angelika FeldmanniD· 1 shared Elzo de WitiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMolecular Biology

Robert J. KloseORCID

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4 papers

Recent·Most cited

SET1/MLL complexes control transcription independently of H3K4me3

Ho Yu Alan Au, Aleksander Szczurek, Inge de Krijger, Nianna Kjelstrup-Osorio, Amy L. Hughes, Anna Lastuvkova, Michiel Vermeulen, Robert J. Klose

The paper identifies a new SET1B complex and shows SET1/MLL complexes control transcription independently of H3K4me3 by counteracting promoter-proximal termination and supporting transcription burst size.

bioRxiv · Dec 10, 2025 · PreprintGenomics

A CpG island-encoded mechanism protects genes from premature transcription termination

Amy L. Hughes, Aleksander Szczurek, Jessica R. Kelley, Anna Lastuvkova, Anne H. Turberfield, Emilia Dimitrova, Neil P. Blackledge, Robert J. Klose

The paper identifies a CpG island-encoded mechanism where SET1 complexes interact with WDR82 to prevent premature transcription termination, distinguishing genic from non-genic transcription.

Nature Communications · Feb 9, 2023Peer-reviewedMolecular Biology

Distinct roles for CDK-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction

Emilia Dimitrova, Angelika Feldmann, Robin H. van der Weide, Koen D. Flach, Anna Lastuvkova, Elzo de Wit, Robert J. Klose

The paper investigates the role of CDK-Mediator in gene regulation, finding it essential for Polycomb-dependent chromosomal interactions and gene priming during differentiation through distinct mechanisms.

bioRxiv · Nov 4, 2021 · PreprintMolecular Biology

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

Nadezda A. Fursova, Anne H. Turberfield, Neil P. Blackledge, Emma L. Findlater, Anna Lastuvkova, Miles K. Huseyin, Paula Dobrinić, Robert J. Klose

The paper shows that BAP1 limits H2AK119ub1 levels, which affects gene expression and Polycomb complex function, revealing a general mechanism for controlling transcriptional potential.

bioRxiv · Nov 13, 2020Molecular Biology