Author

Noortje Kersten

Utrecht UniversityORCID 0000-0003-0348-3370Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Ginny G. Farı́asiD· 5 shared Chun Hei LiiD· 3 shared Maarten A. F. AltelaariD· 3 shared Dan T. M. NguyeniD· 2 shared Max KoppersiD· 2 shared Alessandro Ori‬‬iD· 1 shared Amélie FrealiD· 1 shared Aniruddha MitraiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersCell Biology

Ginny G. Farı́asORCID

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5 papers

Recent·Most cited

Spatiotemporal proteomics elucidates trafficking and localization of Neuroligins to the axon initial segment plasma membrane

Noortje Kersten, Chun Hei Li, Viktor A.B. Al Naqib, Lukas de Haas, Victoria Vataka, Eva van der Meer, Peter Jan Uljee, Guillaine Levenswaard, Maarten A. F. Altelaar, Amélie Freal, Maarten H. P. Kole, Ginny G. Farı́as

The paper uses spatiotemporal proteomics to study the trafficking and localization of NLGN1 and NLGN2 to the axon initial segment, revealing distinct sorting mechanisms and functional roles.

bioRxiv · Jun 19, 2026 · PreprintNeuroscience

Calsyntenin-1 and calsyntenin-3 coordinate TGN exit of axonal cargoes

Derk Draper, Noortje Kersten, Shietela Sewnarain Sukul, Rebecca Jark, Inge Rothuis, Poorvi Ravindra, Aniruddha Mitra, Lukas C. Kapitein, Shawn M. Ferguson, Judith Klumperman, Ginny G. Farı́as

This study investigates the roles of CSTN1 and CSTN3 in axonal cargo transport, finding they coordinate TGN exit and regulate RAB6A levels to influence Golgi organization and trafficking.

bioRxiv · Jun 16, 2026 · PreprintCell Biology

The microcephaly-associated protein YIPF5 differentially regulates ER-export

Francesca Bruno, Mihaela Anitei, Domenico Di Fraia, William Durso, Therese Dau, Emilio Cirri, Mara Sannai, Christina Valkova, Julija Maldutyte, Elizabeth A. Miller, Ignacio Rubio, Vera Garloff, Noortje Kersten, Ginny G. Farı́as, Alessandro Ori‬‬, , Christoph Kaether

This study shows YIPF5 regulates ER export of specific proteins, and its disruption causes neuronal migration defects and microcephaly.

iScience · Jan 27, 2026Peer-reviewedCell Biology

The axonal ER couples translation and secretion machineries for local delivery of axonal transmembrane proteins to promote axonal development

Ha H. Nguyen, Noortje Kersten, Chun Hei Li, Huey de Jong, Tanuj Arora, Themistoklis Liolios, D. Nguyen, Maarten P. Bebelman, Maarten A. F. Altelaar, Max Koppers, Ginny G. Farı́as

The paper identifies a mechanism where axonal ER couples translation and secretion of transmembrane proteins to support axonal development.

bioRxiv · Sep 9, 2025 · PreprintCell Biology

Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons

Chun Hei Li, Noortje Kersten, Nazmiye Özkan, Dan T. M. Nguyen, Max Koppers, Harm Post, Maarten A. F. Altelaar, Ginny G. Farı́as

The paper develops POTATOMap to study biosynthetic lysosomal protein trafficking in neurons, revealing domain-specific mechanisms and interactions.

Nature Communications · Dec 30, 2024Peer-reviewedCell Biology