Francesca M. Brett

This study shows that P2X7R antagonists enhance the effectiveness of anti-seizure medications in human epileptic brain tissue by reducing inflammation and improving drug response.

This study shows that immunoproteasome deficiency accelerates brain aging and causes epilepsy in mice, with reduced immunoproteasome expression also observed in human epilepsy patients.

This paper demonstrates the effectiveness of antimiR-134 in reducing miR-134 levels in human brain tissue sections, supporting its potential as a treatment for pharmacoresistant epilepsy.

This paper identifies five new genetic risk loci for Lewy body dementia through whole-genome sequencing and shows shared risk profiles with Alzheimer’s and Parkinson’s disease.