Donncha F. O’Brien

This study shows that P2X7R antagonists enhance the effectiveness of anti-seizure medications in human epileptic brain tissue by reducing inflammation and improving drug response.

This study shows that tight junctions and cell-matrix adhesions in brain endothelial cells reciprocally control blood-brain barrier integrity through mechanical forces and protein expression changes.

This study uses explanted SEEG electrodes to integrate RNA sequencing, DNA methylation, and genomic data with electrophysiological recordings, revealing distinct molecular landscapes in epilepsies and identifying potential seizure zones.

This study shows that immunoproteasome deficiency accelerates brain aging and causes epilepsy in mice, with reduced immunoproteasome expression also observed in human epilepsy patients.

This paper demonstrates the effectiveness of antimiR-134 in reducing miR-134 levels in human brain tissue sections, supporting its potential as a treatment for pharmacoresistant epilepsy.

This study identifies widespread changes in mRNA polyadenylation in temporal lobe epilepsy, highlighting the role of CPEB4 in seizure severity and neurodegeneration.