Author

Kieron J. Sweeney

Beaumont HospitalORCID 0000-0002-2282-6554Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:electronic health records· 2 Research Focus:gene regulatory network inference· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Donncha F. O’Brien· 4 shared David Clifford HenshalliD· 3 shared Alan BeausangiD· 2 shared Austin Lacey· 2 shared Francesca M. BrettiD· 2 shared Mark O. CunninghamiD· 2 shared Norman DelantyiD· 2 shared Adam S. McGlincheyiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersNeuroscience

Donncha F. O’Brien

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue

Ana Fernandez Martin, Beatriz Gil, Meghma Mitra, Jaideep Kesavan, Austin Lacey, Meng-Juan Sun, Anne Marie O'Callaghan, Vincent Healy, Norman Delanty, Alan Beausang, Francesca M. Brett, Michael A. Farrell, Jane Cryan, Donncha F. O’Brien, Kieron J. Sweeney, , Tobías Engel

This study shows that P2X7R antagonists enhance the effectiveness of anti-seizure medications in human epileptic brain tissue by reducing inflammation and improving drug response.

bioRxiv · Sep 24, 2026 · PreprintNeuroscience

Endothelial tight junctions and cell-matrix adhesions reciprocally control blood-brain barrier integrity

Gergő Porkoláb, Lucien Lemaitre, Beatrix Magyaródi, Imola Rajmon, Tibor Novák, Bálint Barna H. Kovács, Ilona Gróf, Anikó Szecskó, Kinga Dóra Kovács, Enikő Farkas, Boglárka Kovács, Inna Székács, Attila G. Végh, Yosuke Hashimoto, Chris Greene, , Mária A. Deli

This study shows that tight junctions and cell-matrix adhesions in brain endothelial cells reciprocally control blood-brain barrier integrity through mechanical forces and protein expression changes.

bioRxiv · Sep 6, 2025 · PreprintNeuroscience

High-Resolution Multimodal Profiling of Human Epileptic Brain Activity via Explanted Depth Electrodes

Anuj Kumar Dwiwedi, Arun Mahesh, Albert Sanfeliu, Julian Larkin, Rebecca A. Siwicki, Kieron J. Sweeney, Donncha F. O’Brien, Peter Widdess‐Walsh, Simone Picelli, David Clifford Henshall, Vijay Kumar Tiwari

This study uses explanted SEEG electrodes to integrate RNA sequencing, DNA methylation, and genomic data with electrophysiological recordings, revealing distinct molecular landscapes in epilepsies and identifying potential seizure zones.

bioRxiv · Jul 3, 2024 · PreprintGenomics

MicroRNA inhibition using antimiRs in acute human brain tissue sections

Gareth Morris, Elena Langa, Conor Fearon, Karen Conboy, Kelvin Lau E. How, Amaya Sanz‐Rodriguez, Donncha F. O’Brien, Kieron J. Sweeney, Austin Lacey, Norman Delanty, Alan Beausang, Francesca M. Brett, Jane B. Cryan, Mark O. Cunningham, David Clifford Henshall

This paper demonstrates the effectiveness of antimiR-134 in reducing miR-134 levels in human brain tissue sections, supporting its potential as a treatment for pharmacoresistant epilepsy.

Epilepsia · Jun 3, 2022Peer-reviewedNeuroscience