Author

Beniamin Krupkin

University of California, San FranciscoORCID 0000-0002-7457-7342Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:software / tool· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Ahituv NadaviD· 2 shared Alejandro BarreraiD· 1 shared Ali HassaniD· 1 shared Andrew D. NelsoniD· 1 shared Arjun Devadas VasanthakumariiD· 1 shared Atehsa SahaguniD· 1 shared Caroline M. Keeshen· 1 shared Coline ArnouldiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Ahituv NadavORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Uniform processing and analysis of IGVF massively parallel reporter assay data with MPRAsnakeflow

Jonathan D. Rosen, Arjun Devadas Vasanthakumari, Kilian Salomon, Nikola de Lange, Pyaree Mohan Dash, Pia Keukeleire, Ali Hassan, Alejandro Barrera, Beniamin Krupkin, Grace Oualline, Martin Kircher, Michael I. Love, Max Schubach

The paper introduces standardized formats and tools for processing MPRA data to improve reproducibility and integration across studies.

Genome Research · Sep 1, 2026Peer-reviewedGenomics

Massively parallel reporter assays for CYP3A4 enhancer variants alongside their native promoter

Yelena Guttman, Beniamin Krupkin, Ahituv Nadav

The paper uses a modified MPRA to assess CYP3A4 enhancer variants with their native promoter, identifying variants with significant regulatory impact on drug response and cancer severity.

bioRxiv · Apr 24, 2026 · PreprintGenetics

CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

Serena Tamura, Andrew D. Nelson, Perry W.E. Spratt, Elizabeth C. Hamada, Xujia Zhou, Henry Kyoung, Zizheng Li, Coline Arnould, Vladyslav Barskyi, Beniamin Krupkin, Kiana Young, Jingjing Zhao, Stephanie S. Holden, Atehsa Sahagun, Caroline M. Keeshen, , Kevin J. Bender

This study shows that CRISPR activation can rescue electrophysiological deficits in SCN2A haploinsufficiency by increasing the expression of the remaining functional allele in mice and human neurons.

Nature · Sep 17, 2025Peer-reviewedNeuroscience