Theodora U. J. Bruun

This paper describes engineering hematopoietic stem cells to produce CCR5 knockout cells and secrete HIV-1 inhibiting antibodies, aiming for a one-time cure for HIV-1.

This paper develops a multivalent liposomal hydrogel vaccine that generates broad and durable anti-coronavirus antibody responses in mice.

This study uses the PMD immunofocusing technique to create RBD immunogens that induce broadly neutralizing antibodies against the conserved cryptic face of SARS-CoV-2.

This paper uses a structure-informed language model for unsupervised antibody evolution, achieving significant improvements in neutralization and affinity against viral variants.

Consensus likelihoods from general, unsupervised protein language models evolve seven human antibodies using only a wildtype sequence and <=20 tested variants, improving binding affinity up to 160-fold.