Author

Alexandria R. Sprules

University of SheffieldORCID 0000-0002-7510-2891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alexander W. CookiD· 1 shared Ália dos SantosiD· 1 shared Christopher P. ToselandiD· 1 shared Danielle LambertiD· 1 shared Hyejeong Rosemary KimiD· 1 shared Isabel W. Shahid-Fuente· 1 shared Jesse AaroniD· 1 shared Lin WangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexander W. CookORCID

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1 paper

Recent·Most cited

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells.

Yukti Hari‐Gupta, Danielle Lambert, Isabel W. Shahid-Fuente, Natalia Fili, Ália dos Santos, Alexandria R. Sprules, Hyejeong Rosemary Kim, Alexander W. Cook, Peter J. I. Ellis, Jesse Aaron, Teng‐Leong Chew, Lin Wang, Christopher P. Toseland

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

bioRxiv · Nov 13, 2025 · PreprintCancer Biology