Author

Chiara Cerrato

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4 Cancer Biology· 1

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Organism:C. elegans· 4 Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Assay:ChIP-seq· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Julie AhringeriD· 4 shared Alex Appert· 3 shared Dong YaniD· 3 shared Francesco Nicola CarelliiD· 2 shared Jacques SerizayiD· 2 shared Jürgen JänesiD· 2 shared Ni HuangiD· 2 shared Abby F. DernburgiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersGenomics

Julie AhringerORCID

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5 papers

Recent·Most cited

CISH, a novel intracellular immune checkpoint, in comparison and combination to existing and emerging cancer immune checkpoints

Florencia Cano, Alberto Bravo‐Blas, Mathilde Colombé, Chiara Cerrato, Ram Venegalla, Olivier Preham, Ellie Burns, Paige M Mortimer, Nicholas J. Slipek, Matthew J. Johnson, Beau R. Webber, Branden S. Moriarity, Emil Lou, Modassir S. Choudhry, Christopher Austin Klebanoff, Tom Henley

This study shows that deleting CISH enhances T cell anti-cancer functions more than other intracellular checkpoints, improving tumor antigen recognition and killing in CAR-T cells.

bioRxiv · Apr 26, 2025 · PreprintCancer Biology

Widespread transposon co-option in the Caenorhabditis germline regulatory network

Francesco Nicola Carelli, Chiara Cerrato, Dong Yan, Alex Appert, Abby F. Dernburg, Julie Ahringer

The paper shows that transposon expansions in Caenorhabditis nematodes rewired germline transcriptional regulation, with one third of germline-specific promoters co-opted from MITEs.

Science Advances · Dec 16, 2022Peer-reviewedGenomics

DREAM represses distinct targets by cooperating with different THAP domain proteins

Csenge Gal, Francesco Nicola Carelli, Alex Appert, Chiara Cerrato, Ni Huang, Dong Yan, Jane Murphy, Andrea Frapporti, Julie Ahringer

The paper shows that DREAM complex represses distinct gene targets in C. elegans through cooperation with different THAP domain proteins, LIN-36 and LIN-15B, which use separate mechanisms.

Cell Reports · Oct 1, 2021Peer-reviewedGenomics

Tissue-specific profiling reveals distinctive regulatory architectures for ubiquitous, germline and somatic genes

Jacques Serizay, Yan Dong, Jürgen Jänes, Michael A. Chesney, Chiara Cerrato, Julie Ahringer

The paper identifies distinct regulatory architectures for ubiquitous, germline, and somatic genes in C. elegans by analyzing promoter features across five tissues.

Genome Research · Dec 1, 2020Peer-reviewedGenomics

Chromatin accessibility is dynamically regulated across C. elegans development and ageing

Jürgen Jänes, Dong Yan, Michael Schoof, Jacques Serizay, Alex Appert, Chiara Cerrato, Carson Woodbury, Ron Chen, Carolina Gemma, Ni Huang, Djem U. Kissiov, Przemysław Stempor, Annette Steward, Eva Zeiser, Sascha Sauer, Julie Ahringer

The paper maps regulatory elements across C. elegans development and ageing, identifying promoters and enhancers and showing their dynamic accessibility linked to developmental processes.

eLife · Oct 26, 2018Peer-reviewedGenomics