Nicole Bechmann

Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cells

This study identifies SOX2+ cells in phaeochromocytomas and paragangliomas as potential tumour-initiating stem cells capable of expansion and metastasis.

Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas

This study uses patient-derived organoids to model pheochromocytomas and paragangliomas, revealing hypoxia-driven plasticity and therapeutic vulnerabilities, including responses to abemaciclib.

Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes

This study links EPAS1HIF2 genetic adaptations in high-altitude populations to similar mutations in hypoxia-driven tumors, showing shared mechanisms in hypoxia response and tumorigenesis.

A genetic signature predicts aggressive paraganglioma sensitivity to dual PI3K-CDK4/6 inhibition therapy

HIF1α controls steroidogenesis under acute hypoxic stress

This study investigates how HIF1α regulates steroidogenesis under acute hypoxia using cell lines, ex vivo models, and mice, finding HIF1α-dependent miRNA regulation and translational control of steroidogenic enzymes.

Identification of a novel papillary renal cell carcinoma molecular subtype characterized by HIF-pathway over-activation

This paper identifies a novel molecular subtype of papillary renal cell carcinoma (pRCC) characterized by HIF-pathway overactivation, associated with poor prognosis and distinct biological features.

Hypoxia pathway proteins regulate the synthesis and release of epinephrine in the mouse adrenal gland

This study shows that PHD2-HIF2 pathway regulates epinephrine synthesis and release in mouse adrenal glands, linking hypoxia signaling to catecholamine production and systemic glucose levels.

HIF1α is an essential regulator of steroidogenesis in the adrenal gland

This study shows HIF1α is crucial for steroid hormone production in adrenal cells, with its absence increasing steroid levels and overexpression reducing them, affecting systemic health.