This study examines the causal relationship between amyloid-beta biomarkers and total Tau in twins, finding no direct causal link but suggesting a causal impact on neurofilament light chain.

Aging Brain · Jan 1, 2025Peer-reviewedPathology

The genetic and environmental etiology of blood-based biomarkers related to the risks of Alzheimer's Disease in a population-based sample of early old age men

Nathan A. Gillespie, Robert A. Rissman, Jeremy A. Elman, Ruth E. McKenzie, Xin Ming Tu, Hong Xian, Chandra A. Reynolds, Matthew S. Panizzon, Michael J. Lyons, Graham M.L. Eglit, Michael Churton Neale, Carol E. Franz, William S. Kremen

This study investigates the genetic and environmental factors influencing blood-based biomarkers related to Alzheimer's disease risk in middle-aged men.

bioRxiv · Aug 9, 2022 · PreprintGenetics

The genetic etiology of longitudinal measures of predicted brain ageing in a population-based sample of mid to late-age males

Nathan A. Gillespie, Sean N. Hatton, Donald J. Hagler, Anders Martin Dale, Jeremy A. Elman, Linda K. McEvoy, Lisa T Elyer, Christine Fennema‐Notestine, Mark W. Logue, Ruth E. McKenzie, Olivia K. Puckett, Xin Ming Tu, Nathan A. Whitsel, Hong Xian, Chandra A. Reynolds, , Carol E. Franz

This study investigates the genetic and environmental factors influencing longitudinal predicted brain ageing (PBA) using MRI data from mid to late-age males, finding significant genetic heritability and stability over time.

bioRxiv · Aug 4, 2021 · PreprintGenetics

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

Carol E. Franz, Sean N. Hatton, Jeremy A. Elman, Teresa S. Warren, Nathan A. Gillespie, Nathan A. Whitsel, Olivia K. Puckett, Anders Martin Dale, Lisa T. Eyler, Christine Fennema‐Notestine, Donald J. Hagler, Richard L. Hauger, Ruth E. McKenzie, Michael Churton Neale, Matthew S. Panizzon, , William S. Kremen

This study examines how early midlife lifestyle behaviors and young adult cognitive reserve influence late midlife brain aging and mild cognitive impairment.

bioRxiv · Nov 2, 2020 · PreprintNeuroscience

Baseline Semantic Fluency Is Associated with Six-Year Progression to Mild Cognitive Impairment in Middle-Aged Men

Daniel E. Gustavson, Jeremy A. Elman, Matthew S. Panizzon, Carol E. Franz, Jordan Zuber, Mark E. Sanderson‐Cimino, Chandra A. Reynolds, Kristen C. Jacobson, Hong Xian, Amy J. Jak, Rosemary Toomey, Michael J. Lyons, William S. Kremen

The paper shows that poor episodic memory and semantic verbal fluency in middle-aged men predict progression to mild cognitive impairment within six years.

Neurology · Jun 30, 2020Peer-reviewedGenetics