Jeremy A. Elman

Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis

IBMMA improves neuroimaging analysis by handling missing data and large datasets, revealing new brain region findings overlooked by traditional methods.

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins.

This study examines the causal relationship between amyloid-beta biomarkers and total Tau in twins, finding no direct causal link but suggesting a causal impact on neurofilament light chain.

Detecting boolean asymmetric relationships with a loop counting technique and its implications for analyzing heterogeneity within gene expression datasets

The paper introduces a method to detect boolean asymmetric relationships in gene expression data, identifying heterogeneity driven by asymmetric gene interactions and showing improved classifier performance.

Exploring the genetic heterogeneity of Alzheimer's disease: Evidence for genetic subtypes

The paper identifies genetic subtypes of Alzheimer's disease using PCA and biclustering, finding two disease-specific genetic signatures associated with cognitive decline and pathological markers.

The genetic and environmental etiology of blood-based biomarkers related to the risks of Alzheimer's Disease in a population-based sample of early old age men

This study investigates the genetic and environmental factors influencing blood-based biomarkers related to Alzheimer's disease risk in middle-aged men.

Brain charts for the human lifespan

The paper introduces brain charts as a standardized resource for benchmarking brain morphology across the human lifespan using MRI data from a large and diverse cohort.

The genetic etiology of longitudinal measures of predicted brain ageing in a population-based sample of mid to late-age males

This study investigates the genetic and environmental factors influencing longitudinal predicted brain ageing (PBA) using MRI data from mid to late-age males, finding significant genetic heritability and stability over time.

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

This study examines how early midlife lifestyle behaviors and young adult cognitive reserve influence late midlife brain aging and mild cognitive impairment.

Baseline Semantic Fluency Is Associated with Six-Year Progression to Mild Cognitive Impairment in Middle-Aged Men

The paper shows that poor episodic memory and semantic verbal fluency in middle-aged men predict progression to mild cognitive impairment within six years.

The genetic organization of subcortical volumetric change is stable throughout the lifespan

This paper identifies stable developmental clusters of subcortical volumetric change across the lifespan and shows genetic organization within these clusters.

Aβ-Positivity Predicts Cognitive Decline but Cognition Also Predicts Progression to Aβ-Positivity

The paper shows that cognitive function predicts progression to Aβ-positivity, even when controlling for baseline biomarker levels, suggesting cognitive measures may identify early AD risk.

Pupillary dilation responses as a midlife indicator of risk for Alzheimer’s Disease: Association with Alzheimer’s disease polygenic risk

The paper shows that higher Alzheimer’s disease polygenic risk scores are linked to greater pupillary dilation during cognitive tasks in midlife, suggesting a genetic biomarker for early AD risk.

Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group

This study identifies hippocampal subfield volume differences in PTSD and depression across 31 cohorts, finding depression has a stronger effect than PTSD, especially in CA1, with comorbid cases showing more pronounced changes.

Genetic risk for coronary heart disease alters the influence of Alzheimer’s genetic risk on mild cognitive impairment

The paper examines how genetic risk for coronary heart disease interacts with Alzheimer’s genetic risk to influence mild cognitive impairment risk in a cohort of 1,209 individuals.