Michael J. Lyons

IBMMA improves neuroimaging analysis by handling missing data and large datasets, revealing new brain region findings overlooked by traditional methods.

This study examines the causal relationship between amyloid-beta biomarkers and total Tau in twins, finding no direct causal link but suggesting a causal impact on neurofilament light chain.

The paper estimates genetic and environmental contributions to module eigengenes (MEs) derived from blood lymphocytes in older male twins, finding significant heritability in 56% of detected MEs.

This study finds smaller total and subregional cerebellar volumes in PTSD compared to controls using a large dataset and advanced parcellation methods.

This study investigates the genetic and environmental factors influencing blood-based biomarkers related to Alzheimer's disease risk in middle-aged men.

This study investigates the genetic and environmental factors influencing longitudinal predicted brain ageing (PBA) using MRI data from mid to late-age males, finding significant genetic heritability and stability over time.

The paper identifies seven metabolites associated with executive function decline in early Alzheimer’s disease using longitudinal plasma samples from the WRAP cohort.

This study examines how early midlife lifestyle behaviors and young adult cognitive reserve influence late midlife brain aging and mild cognitive impairment.

The paper shows that poor episodic memory and semantic verbal fluency in middle-aged men predict progression to mild cognitive impairment within six years.

The paper shows that cognitive function predicts progression to Aβ-positivity, even when controlling for baseline biomarker levels, suggesting cognitive measures may identify early AD risk.

The paper shows that higher Alzheimer’s disease polygenic risk scores are linked to greater pupillary dilation during cognitive tasks in midlife, suggesting a genetic biomarker for early AD risk.

This study identifies hippocampal subfield volume differences in PTSD and depression across 31 cohorts, finding depression has a stronger effect than PTSD, especially in CA1, with comorbid cases showing more pronounced changes.

This study identifies reduced fractional anisotropy in the tapetum region of the corpus callosum in PTSD patients using a large multi-cohort analysis of diffusion MRI data.

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

The paper examines how genetic risk for coronary heart disease interacts with Alzheimer’s genetic risk to influence mild cognitive impairment risk in a cohort of 1,209 individuals.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

The paper investigates whether cortical size mediates the association between height and cognitive ability using twin data.