Author

Fengbiao Zhou

Heidelberg UniversityORCID 0000-0002-9221-1096Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Carsten Müller‐TidowiD· 2 shared Christian RohdeiD· 2 shared Anke Heit-Mondrzyk· 1 shared Annika Lauk· 1 shared C.T. LiuiD· 1 shared Cathrine Broberg VågbøiD· 1 shared Claudia Dorothea BaldusiD· 1 shared Cornelius PauliiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Carsten Müller‐TidowORCID

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2 papers

Recent·Most cited

Integrated scFv identification and CAR T cell generation for AML targeting in vivo

Yi Liu, Annika Lauk, David N. Sedloev, Josephine Brysting, Ela Cetin, C.T. Liu, Maximilian Mönnig, Thomas Luft, Haiyang Yun, Michael W. Schmitt, Tim Sauer, Fengbiao Zhou, Christian Rohde, Carsten Müller‐Tidow

This study integrates scFv development with CAR T cell generation to target CLL1-positive AML, showing effective tumor killing in vivo.

International Journal of Cancer · Oct 2, 2025Peer-reviewedImmunology

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

Cornelius Pauli, Michael Kienhöfer, Maximilian Felix Blank, Oguzhan Begik, Christian Rohde, Daniel Heid, Fu Yong Xu, Sarah Miriam Naomi Zimmermann, Katharina Weidenauer, Sylvain Delaunay, Nadja Krall, Katrin Trunk, Duoduo Zhao, Fengbiao Zhou, Anke Heit-Mondrzyk, , Michaela Frye

The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.

bioRxiv · Jul 13, 2024 · PreprintCell Biology