Daniel Heid

WarpDemuX-custom - Multiplexed sequence-specific direct RNA sequencing

The paper introduces an improved protocol and software for sequence-specific direct RNA sequencing of non-polyadenylated RNAs, validated on human rRNA and other RNA species.

An Fc-SPINK1 fusion protein inhibits pancreatic inflammation in a mouse model

This paper develops an Fc-SPINK1 fusion protein that reduces pancreatic inflammation in mice by extending its half-life and inhibiting trypsin activity.

Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures

The paper uses rRNA modification patterns to identify tissue and tumor-specific signatures, showing their potential as diagnostic biomarkers.

A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins

The paper develops a deep mutational scanning pipeline for anti-CRISPR proteins in E. coli, revealing their mutational tolerance and redundancy, and validates findings in mammalian cells.

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.