Kwangsik T. Nho

The paper identifies a functionally connected subnetwork of 276 multi-omic biomarkers for Alzheimer’s Disease using a modularity-constrained Lasso model applied to the ROS/MAP cohort.

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

This study uses an epidemic spreading model to show that tau spreads through neuronal connections in Alzheimer's disease, with beta-amyloid accelerating this process in some brain regions.

The paper identifies a rare PLCG2 variant that increases Alzheimer's disease risk and shows increased PLCG2 expression correlates with amyloid deposition in AD patients.

The paper investigates the association between elevated plasma cortisol and brain volume changes in elderly cohorts, finding larger ventricles and smaller hippocampal volumes.

The paper investigates sex and APOE ε4 genotype effects on metabolic alterations in Alzheimer’s disease using stratified analysis of serum metabolites.

The paper integrates genomic and metabolomic data with biological networks to identify genetic variants and bile acids associated with Alzheimer's disease, revealing functional biological paths across multiple-omics layers.

The paper identifies differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease by analyzing transcriptomes and metabolomics data from brain samples.

This study compares whole hippocampus and subfield biomarkers for Alzheimer’s disease detection and prediction using multimodal MRI data, finding subiculum biomarkers improve prediction accuracy.

The paper investigates the association between triglyceride principal component scores and Alzheimer's disease biomarkers in the ADNI cohort, finding significant links with MCI, AD, and specific brain structures.

The paper identifies lipid sets in blood associated with Alzheimer's disease biomarkers and clinical symptoms using lipidomic profiling in the ADNI1 cohort.

The paper examines microglial activation in elderly brains, finding strong associations with neuropathology and cognitive decline, and identifies genetic overlaps with Alzheimer's disease.

The paper identifies altered bile acid profiles in Alzheimer's disease, linking them to cognitive impairment and genetic variants through a large study.

The paper identifies associations between serum bile acid metabolites and AD biomarkers in the A/T/N framework, suggesting a potential role for bile acid pathways in AD pathophysiology.

The paper examines the heritability of regional brain volumes using genetic and neuroimaging data from multiple cohorts, finding high heritability and consistent patterns across populations.

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.