Aleksandra Skirycz

Hopeaphenol targets histidine kinase signaling across kingdoms to suppress bacterial virulence and potentiate plant immunity

Hopeaphenol inhibits histidine kinase signaling in both bacterial pathogens and plant hosts, reducing virulence and enhancing immunity.

Cystinosin/Ers1 functions in redox homeostasis in the early secretory pathway

This study identifies a conserved role of cystinosin/Ers1 in the early secretory pathway, revealing new insights into cystinosis pathology beyond lysosomal cystine transport.

Multi-tissue metabolic GWAS and drought-responsive multi-omics reveal the genetic basis of the quinoa metabolome

This study integrates multi-omics data from quinoa to identify genetic factors controlling its metabolome and stress response, revealing key genes involved in metabolite biosynthesis.

The mRNA covalent modification dihydrouridine regulates transcript turnover and photosynthetic capacity during plant abiotic stress

This study identifies dihydrouridine (DHU) modification as a regulator of transcript turnover and photosynthetic capacity in plants under abiotic stress.

Chemical modulation of chloroplast de- and re-differentiation reveals a role for the SAL1-PAP retrograde pathway in facilitating plastid transitions

The paper shows that X57 modulates chloroplast transitions by inhibiting SAL1, leading to PAP accumulation and changes in gene expression that facilitate plastid de- and re-differentiation.

Identification of dehydrin protein complexes in vivo reveals functional interactions of LEA5 with OSCA3, PIP2B and PLDα1 in plant water-deficit stress

This study identifies in vivo interactions of LEA proteins with molecular targets in plant water-deficit stress and reveals their functional roles in stress tolerance.

Small molecule oxybutynin rescues proliferative capacity of complex III-defective MPCs

This study shows that oxybutynin rescues proliferative capacity and metabolic function in Complex III-defective mitochondrial progenitor cells.

Multi-Omics Analysis of Heat Stress-Induced Memory in Arabidopsis

This study uses multi-omics analysis to investigate heat stress memory in Arabidopsis, identifying temporal transcriptomic, proteomic, and metabolomic responses during recovery.

Mapping protein-metabolite interactions in E. coli by integrating chromatographic techniques and co-fractionation mass spectrometry.

The paper introduces PROMIS, a co-fractionation mass spectrometry technique integrated with chromatographic methods to map protein-metabolite interactions in E. coli, identifying 994 interactions and revealing novel functional insights.

Identification of cell-type-specific response to silicon treatment in soybean leaves through single nucleus RNA-sequencing

This study uses snRNA-seq to identify cell-type-specific responses to silicon treatment in soybean leaves, revealing novel Si-induced cell clusters and gene expression changes related to defense mechanisms.

The transcription factor ATML1 maintains giant cell identity by inducing synthesis of its own (very) long-chain fatty acid-containing ligands

The paper shows that high ATML1 concentrations induce VLCFA synthesis, which maintains giant cell identity by promoting auto-activation through lipid ligand binding.

Hello darkness, my old friend: 3-Ketoacyl-Coenzyme A Synthase4 is a branch point in the regulation of triacylglycerol synthesis in Arabidopsis

Natural variation at KCS4 underlies differential accumulation of polyunsaturated triacylglycerols under carbon starvation by acting as a regulatory branch point in fatty acid fate.

Identification and Functional Annotation of Long Intergenic Non-coding RNAs in the Brassicaceae

The paper identifies and functionally annotates ~130,000 lincRNAs in four Brassicaceae species using RNA-seq and epigenomic data, highlighting conserved motifs and stress-responsive features.

SLIMP: Supervised learning of metabolite-protein interactions from co-fractionation mass spectrometry data

SLIMP predicts metabolite-protein interactions using supervised machine learning on co-fractionation mass spectrometry data, identifying over 9,000 and 20,000 interactions in yeast and Arabidopsis.