Tobias Schmidt

Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition

This study identifies ceramide-driven lipotoxicity as a driver of calcific aortic valve disease and shows that SPT inhibition can reverse disease progression in vivo.

Ovarian cancer-on-chip for patient-specific profiling of treatment responses to sequential chemotherapy and PD-L1 blockade

This paper develops an OvCa-on-chip platform to profile patient-specific treatment responses to chemotherapy and PD-L1 blockade.

Engineered and decellularized human cartilage graft exhibits intrinsic immuno-evasive properties and full skeletal repair capacity

This study engineers and decellularizes human cartilage grafts, demonstrating their immuno-evasive properties and ability to repair skeletal defects in rats.

Virtual Tissue Expression Analysis

The paper introduces tissueResolver, an algorithm that infers single-cell type information from bulk RNA-seq data, revealing cell-type-specific regulatory differences in DLBCL subtypes.

Single step, high efficiency CRISPR-Cas9 genome editing in primary human disease-derived fibroblasts

This study develops a single-step CRISPR-Cas9 method for high-efficiency genome editing in primary human fibroblasts without antibiotic selection or clonal expansion, achieving >90% knockout efficiency.