Erlend Bøen

Thalamic Nuclei Volumes Across Psychiatric and Neurological Disorders: A Multi-Site Magnetic Resonance Imaging Study

This study compares thalamic nucleus volumes across multiple psychiatric and neurological disorders using MRI, finding significant volume reductions in specific regions associated with different conditions.

Evidence for widespread alterations in cortical microstructure after 32 hours of sleep deprivation

This study shows that 32 hours of sleep deprivation increases the T1w/T2w ratio in specific cortical regions compared to a normal sleep-wake cycle.

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.

The genetic architecture of human brainstem structures and their involvement in common brain disorders

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

This paper examines brain aging in major depressive disorder (MDD) using a large dataset, finding that MDD patients show increased brain age differences compared to controls.

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

The paper examines common genetic variants' contribution to bipolar disorder risk in multiplex families and finds higher polygenic risk scores in affected individuals compared to controls and unaffected family members.

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

This study identifies 73 genome-wide significant loci for mood disorders, revealing shared and distinct genetic factors between major depressive disorder and bipolar disorder.

Genetics of brain age suggest an overlap with common brain disorders

The paper estimates brain age gaps using MRI and machine learning in individuals with and without brain disorders, finding heritability and genetic overlap with common disorders.

Genomewide association study identifies 30 loci associated with bipolar disorder

This study identifies 30 genome-wide significant loci associated with bipolar disorder, including novel genes involved in ion channels, neurotransmitters, and synaptic components.