Photini Sinnis

This study identifies a PX1 haplotype in Plasmodium falciparum associated with reduced susceptibility to artemisinin and lumefantrine, providing a marker for drug resistance surveillance.

This paper identifies UCB-9721 as a potent inhibitor of T. gondii MyoA, showing greater potency than KNX-002 and inhibiting related apicomplexan parasites.

This study identifies PfMD3 as an RNA-binding protein that regulates male gamete fertility by impacting translation in Plasmodium falciparum.

This study identifies and characterizes long non-coding RNAs in Plasmodium falciparum across asexual and gametocyte stages using long-read sequencing and single-cell transcriptomics.

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

This study uses high-resolution proteomics to show that Plasmodium infection disrupts mosquito salivary glands, causing exchange of proteins between hemolymph and saliva.

This study investigates rRNA dynamics in Plasmodium falciparum during gametocytogenesis, revealing specific degradation patterns and shifts in rRNA types across developmental stages.

This study identifies DMT1 and a chromosome 12 locus, including FtsH1, as novel contributors to Plasmodium falciparum resistance to quinine, alongside the known pfcrt gene.

This study confirms that the circumsporozoite protein (CSP) of Plasmodium sporozoites is GPI-anchored using metabolic labeling and mass spectrometry.

The paper identifies genetic determinants of multidrug resistance in Plasmodium falciparum and their impact on parasite fitness and drug susceptibility.

The paper generates transgenic Plasmodium falciparum parasites with fluorescent transmission stages for improved study and screening.

This study examines changes in genome organization during the transmission stages of Plasmodium parasites and finds that three-dimensional genome structure is linked to transcriptional activity of gene families involved in pathogenesis and immune evasion.