Elisabetta Moroni

Disulfide-mediated tetramerization of TRAP1 fosters its antioxidant and pro-neoplastic activities.

This study shows TRAP1 forms redox-sensitive tetramers via disulfide bonds, which are critical for its antioxidant and pro-neoplastic functions in cancer cells.

Molecular Structure and Enzymatic Mechanism of the Human Collagen Hydroxylysine Galactosyltransferase GLT25D1/COLGALT1

This study characterizes the molecular structure and enzymatic mechanism of GLT25D1/COLGALT, identifying its catalytic site and dimeric assembly as critical for collagen lysine modification.

Point mutations of the mitochondrial chaperone TRAP1 affect its functions and pro-neoplastic activity.

This study examines how point mutations in TRAP1 affect its structure, function, and pro-neoplastic activity using molecular dynamics simulations and structural analysis.

Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes