Negar Fani

Childhood Maltreatment and Deviations from Normative Brain Structure: Results from 3,711 Individuals from the ENIGMA MDD and ENIGMA PTSD

The paper examines how childhood maltreatment affects brain structure in 3,711 individuals with MDD and PTSD, finding age- and sex-specific brain morphometric differences.

Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis

IBMMA improves neuroimaging analysis by handling missing data and large datasets, revealing new brain region findings overlooked by traditional methods.

Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology

The paper examines thalamic volume differences in trauma-exposed individuals with PTSD, MDD, and controls, finding specific volume reductions and associations with symptom severity and childhood trauma.

Assessing the distinct contributions of rostral and dorsomedial prefrontal cortex to cognitive control using temporal interference brain stimulation

This study uses temporal interference stimulation to examine the distinct roles of dmPFC and rmPFC in cognitive control, finding differential effects on reaction times and accuracy in Stroop tasks.

Neural Domains Associated with Substance Use Disorders: A Systematic Review of Neuroimaging Studies

This review examines neural domains linked to substance use disorders, finding altered activation in reward and inhibition processes but no trauma-exposed studies meeting criteria.

Neurophysiological Changes Associated with Vibroacoustically-augmented Breath-focused Mindfulness for Dissociation: Targeting Interoception and Attention

This study evaluates the effects of vibroacoustically-augmented breath-focused mindfulness on interoception, attention, and autonomic regulation in trauma-exposed women with dissociative symptoms.

Multimodal Imaging-Based Classification of PTSD Using Data-Driven Computational Approaches: A Multisite Big Data Study from the ENIGMA-PGC PTSD Consortium

This paper classifies PTSD vs. controls using MRI data from multiple sites, finding better performance when distinguishing PTSD from trauma-unexposed controls than trauma-exposed controls, and showing DVAE improves generalizability.

Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

This study finds smaller total and subregional cerebellar volumes in PTSD compared to controls using a large dataset and advanced parcellation methods.

A Comparison of Methods to Harmonize Cortical Thickness Measurements Across Scanners and Sites

This paper compares four methods for harmonizing cortical thickness data across multiple sites and finds that ComBat-GAM is most effective in detecting case-control differences and age-related cortical thinning.

Structural Covariance Networks in Post-Traumatic Stress Disorder: A Multisite ENIGMA-PGC Study

This study examines structural covariance networks in PTSD using a large multisite dataset, finding differences in centrality measures between PTSD and control groups, and highlighting sex-based and comorbid differences.

Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group

This study identifies hippocampal subfield volume differences in PTSD and depression across 31 cohorts, finding depression has a stronger effect than PTSD, especially in CA1, with comorbid cases showing more pronounced changes.

Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium

This study identifies reduced fractional anisotropy in the tapetum region of the corpus callosum in PTSD patients using a large multi-cohort analysis of diffusion MRI data.

Genome wide association study of hippocampal subfield volume in PTSD cases and trauma-exposed controls

The paper conducts a GWAS of hippocampal subfield volumes in PTSD cases and trauma-exposed controls, identifying genetic associations and gene-environment interactions.