Dimitri Tränkner

A Microglial Regulatory Program Linked to Neuropsychiatric Disorders

The paper identifies a Hoxb8-dependent transcriptional program in microglia linked to neuropsychiatric disorders through integrated chromatin and transcriptional analyses in mice.

Inhibitory neurons marked by the connectivity molecule Kirrel3 regulate memory precision

This study identifies Kirrel3-expressing inhibitory neurons that regulate memory discrimination in mice by inhibiting CA3 neuron activity during memory recall.

Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus

The paper identifies convergent cis-regulatory elements in hibernators and homeotherms that underlie metabolic responses to fasting and refeeding.

PROX1 Controls Cellular Patterning, Innervation and Differentiation in the Mouse Organ of Corti

This study shows that PROX1 is essential for the differentiation and organization of lateral compartment supporting cells in the mouse organ of Corti, which indirectly affects innervation patterns.

Modular Splicing is Linked to Evolution in the Synapse-Specificity Molecule Kirrel3

The paper characterizes Kirrel3 isoforms in mouse and human brain using long-read sequencing, identifies novel exons, and links splicing diversity to evolutionary changes in synapse-specificity.

The Transcriptional Logic of Mammalian Neuronal Diversity

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.