Yasuyuki Shima

MitoDelta detects mitochondrial DNA deletions at cell-type resolution using single-cell RNA sequencing data, revealing distinct deletion burdens across neuronal subtypes in Parkinson's disease.

This study identifies four cell types in the mouse PVT using single-cell RNA sequencing and shows their transcriptomic continuity along the anterior-posterior axis, with distinct axon projection patterns and functional responses to neuropeptides.

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.

The paper examines the projection patterns of SL and SP neurons in the APC, revealing distinct axonal connections to downstream structures and a hierarchical feedback circuit.