Nelson Spruston

The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.

The paper introduces morphoFISH, a method combining imaging and spatial transcriptomics to identify new neuronal cell types in the mouse brain.

This study uses single-cell RNA sequencing to describe neuronal heterogeneity in the medial septum and diagonal band of Broca, identifying subclusters and explaining conflicting behavioral results.

The paper shows that learning in the hippocampus produces orthogonalized neural representations resembling a state machine, captured by HMMs and biologically plausible networks, but not by gradient-based models.

This paper introduces a neural network model of systems consolidation that optimizes memory transfer for generalization, showing how selective consolidation supports both memory and adaptive behavior.

This study demonstrates meta-learning in head-fixed mice navigating virtual reality by showing increased learning speed and modified motor programs during task changes.

The paper develops DELTA, a method to measure brain-wide synaptic protein turnover at single-synapse resolution, revealing localized plasticity in hippocampal CA1 during learning.

The paper shows that synaptic plasticity in hippocampal neurons helps form a conjunctive code of position and choice during learning.

The paper identifies distinct synaptic microcircuits in the mouse frontal cortex, showing hippocampal and thalamic afferents target different inhibitory and excitatory neuron classes.

The paper describes engineering eFRET voltage indicators with positive-going fluorescence responses by modifying microbial rhodopsins.

The paper identifies a rare, spatially localized granule cell subtype in the hippocampus that is preferentially recruited during memory formation.

ShuTu is a software tool that enables efficient and accurate reconstruction of dendritic morphology from bright-field microscopy images through automated identification and manual correction.

This study uses calcium imaging in mouse motor cortex pyramidal cells to show that dendritic activity during decision-making is compartmentalized by branching and clustered within branches.

This study investigates how context-dependent sensory responses in the hippocampus emerge, finding that CA1 neurons inherit conjunctive codes from CA3 inputs.

The paper reconstructs 1,000 projection neurons in the mouse brain, revealing new cell types and organizational principles of long-range connectivity.

The paper shows astrocytic networks integrate and drive neural activity by influencing inhibitory interneuron firing through calcium signaling and molecular mechanisms.

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.