Xia Wang

This paper identifies loss-of-function variants in ZFHX3 as a cause of syndromic intellectual disability and describes its role in chromatin remodeling and DNA methylation.

This study generates haplotype-resolved assemblies and a variant benchmark for a Chinese monozygotic twin quartet using advanced sequencing and computational methods.

The paper updates TRiP's RNAi and CRISPR fly stocks, presenting over 5,000 CRISPR-OE and -KO stocks for gene activation and knockout studies in Drosophila.

GRIPT is a case-control analysis method for NGS data that improves disease gene discovery, particularly in highly heterogeneous Mendelian diseases.

The paper identifies additional DDX3X variants in individuals with intellectual disability and expands the known phenotypic spectrum of DDX3X disorders.

This paper introduces flySAM, a CRISPRa tool for Drosophila that improves effectiveness, scalability, and ease-of-use compared to existing methods.