Author

Zhulin Hu

Yunnan UniversityORCID 0000-0002-1575-5356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

François Paquet‐DurandiD· 3 shared Jie YaniD· 3 shared Kangwei JiaoiD· 3 shared Lan WangiD· 3 shared Qianlu YangiD· 3 shared Mathias W. SeeligeriD· 2 shared Qianxi YangiD· 2 shared Yujie DongiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

François Paquet‐DurandORCID

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3 papers

Recent·Most cited

PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in rd1 mouse inherited retinal degeneration

Lan Wang, Jie Yan, Javier Sancho-Pellúz, Qianlu Yang, Zhulin Hu, Kangwei Jiao, Mathias W. Seeliger, François Paquet‐Durand

This study investigates the role of PPARs and PGC-1α in photoreceptor neuroprotection in rd1 mouse model of retinal degeneration, finding that their activation reduces photoreceptor death and PARP activity.

bioRxiv · Oct 21, 2025 · PreprintNeuroscience

Resolving the estrogen paradox in hereditary retinal degeneration: Esr1 activation suppresses Tnf-α signaling as a photoreceptor self-protection mechanism

Yuting Li, Yadi Li, Jiarui Luo, Lan Wang, Qianlu Yang, Qianxi Yang, Cong Duan, Wenrong Xu, Yujie Dong, Lei Kong, Yan Li, Wenjia Zhang, Kangwei Jiao, Zhijian Zhao, Christina Schwarz, , Jie Yan

This study identifies Esr1 activation as a protective mechanism against neuroinflammation in retinal degeneration, showing it suppresses Tnf-α signaling and reduces photoreceptor death.

bioRxiv · Sep 7, 2025 · PreprintNeuroscience

Inherited retinal degeneration: T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death.

Jie Yan, Lan Wang, Qianlu Yang, Qianxi Yang, Xinyi He, Yujie Dong, Zhulin Hu, Mathias W. Seeliger, Kangwei Jiao, François Paquet‐Durand

This study investigates the role of calcium signaling in photoreceptor cell death in IRD using mouse models and identifies calpain-2 as a key contributor to degeneration.

Cell Communication and Signaling · Feb 1, 2024Peer-reviewedNeuroscience