Jack T. Stapleton

Systematic genome analysis enables long-overdue taxonomic reorganization of genus Orthoflavivirus; potential assignment of over 50 new species

The paper proposes a genetic divergence threshold for demarcating orthoflavivirus species, identifying 25 new Euflavivirus and 33 new Fusivirus species.

Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation

This study identifies extracellular condensates (ECs) from macaques as endogenous factors that modulate HIV transcription and latency reactivation, with THC treatment altering their anti-inflammatory properties.

Identification of HIV Tat and NF-κB binding proteins associated with semen-derived extracellular vesicles

The paper identifies host proteins in human semen-derived extracellular vesicles that interact with HIV Tat and NF-κB, suggesting they may repress HIV by targeting transcription factors.

Integrated analysis of protein sequence and structureredefines viral diversity and the taxonomy of the Flaviviridae

The paper redefines the taxonomy of Flaviviridae by integrating protein sequence and structure data, revealing new clades and expanding host range.

Immune determinants of pegivirus persistence, control, and cross-species infection in the laboratory mouse

This paper creates a mouse model of pegivirus infection and investigates immune mechanisms of persistence and cross-species infection.