Andrew H. Laszlo

Nanopore tweezers enable monitoring of RNA polymerase II translocation relative to DNA during transcription elongation with single-nucleotide spatial resolution and millisecond-scale temporal resolution at biologically relevant, saturating substrate concentrations.

This study identifies and characterizes nonlinear ion transport phenomena in β-barrel nanopores, linking lumen charge distribution to open-pore rectification and gating.

This study identifies PMPL-1 as a cofactor required for PEEL-1 toxin-induced cell death in C. elegans and shows that the toxin-antidote system creates a cation channel.

This study uses nanopore sequencing to accurately detect sulfation and phosphorylation on plant peptide hormones, demonstrating high sensitivity for identifying sulfotyrosine modifications.