Author

Rajesh K. Mistry

AstraZeneca (United Kingdom)ORCID 0000-0002-9992-8735Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Cristina Sayago Ferreira· 2 shared Diane HattoniD· 2 shared Luigi GrassiiD· 2 shared Noah HitchcockiD· 2 shared Ramy ElgendyiD· 2 shared Catarina FrancoiD· 1 shared Christopher P. ToselandiD· 1 shared Daniel A. BoseiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Cristina Sayago Ferreira

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2 papers

Recent·Most cited

DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture

Noah Hitchcock, Maxine Annoh, Luigi Grassi, Samik Das, Cristina Sayago Ferreira, Daniel Ray, Ramy Elgendy, Lin Wang, Ken Lee, Ian M. Sudbery, Daniel A. Bose, Diane Hatton, Si Nga Sou, Rajesh K. Mistry, Christopher P. Toseland

The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.

bioRxiv · Mar 19, 2026 · PreprintCell Biology

Identification of Cellular Signatures Associated with Chinese Hamster Ovary (CHO) Cell Adaptation for Secretion of Antibodies

Ying Bai, Ivan Domenech Mercadé, Ramy Elgendy, Giulia Lambiase, Sew‐Yeu Peak‐Chew, Catarina Franco, Steven W. Wingett, Tim J. Stevens, Luigi Grassi, Noah Hitchcock, Cristina Sayago Ferreira, Diane Hatton, Elizabeth A. Miller, Rajesh K. Mistry

This study identifies cellular adaptations in CHO cells linked to antibody production, finding that transgene copy number and mRNA expression levels are key factors in productivity.

Computational and Structural Biotechnology Journal · Dec 10, 2024Peer-reviewedBioengineering