David A. DiGregorio

High frequency spike inference with particle Gibbs sampling

This paper introduces a Bayesian method using particle Gibbs sampling to infer high-frequency neuronal spikes and quantify their uncertainty, showing improved performance on benchmark datasets.

Synaptic dynamics are a tunable substrate sculpting neuralpopulation activity

The paper shows that synaptic dynamics shape sparse neural activity patterns in granule cells, tuning them to match learning demands.

Precise calcium-to-spike inference using biophysical generative models

The paper develops biophysically-inspired models to improve spike inference from calcium imaging by accounting for kinetic features of fluorescent indicators.

A dendritic substrate for temporal diversity of cortical inhibition

The paper identifies distinct dendritic integration strategies in two types of cortical interneurons that lead to different temporal dynamics of inhibition.

Demonstration that sublinear dendrites enable linearly non-separable computations

The paper demonstrates that sublinear dendritic summation enables neurons to perform linearly non-separable computations by showing increased spiking probability with scattered synaptic activation.

Synaptic basis of a sub-second representation of time

The paper investigates whether short-term synaptic plasticity can generate neural dynamics for sub-second temporal learning using cerebellar simulations.

Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons

The paper investigates how synaptic integration matures in cerebellar interneurons, finding that changes in synapse distribution, not dendritic properties, drive the development of a two-stage integration model.

Distinct nanoscale calcium channel and synaptic vesicle topographies contribute to the diversity of synaptic function

The paper investigates the nanoscale arrangement of calcium channels and synaptic vesicles in cerebellar synapses, finding distinct topographies that correlate with synaptic strength and functional diversity.

Stability, affinity and chromatic variants of the glutamate sensor iGluSnFR

The paper introduces variants of the glutamate sensor iGluSnFR with improved brightness, broader concentration detection, and different emission colors for enhanced in vivo imaging.