This study develops an in vivo zebrafish screening assay to identify drugs that suppress convulsant-induced neuronal hyperexcitability, finding that Kv7 channel activators are consistently effective.

bioRxiv · May 29, 2026 · PreprintPharmacology & Toxicology

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

Hadeel Alyenbaawi, Richard Kanyo, Laszlo F. Locskai, Razieh Kamali-Jamil, Michèle G. DuVal, Qing Bai, Holger Wille, Edward A. Burton, W. Ted Allison

This study shows that post-traumatic seizures and dynamin-dependent endocytosis promote tauopathy spread after TBI using a zebrafish model.

eLife · Feb 1, 2021Peer-reviewedNeuroscience

A bright and high-performance genetically encoded Ca2+ indicator based on mNeonGreen fluorescent protein

Landon Zarowny, Abhi Aggarwal, Virginia Rutten, Ilya Kolb, The GENIE Project, Ronak H. Patel, Hsin‐Yi Huang, Yu‐Fen Chang, Tiffany Phan, Richard Kanyo, Misha B. Ahrens, W. Ted Allison, Kaspar Podgorski, Robert E. Campbell

The paper develops a new genetically encoded Ca2+ indicator, mNG-GECO1, based on mNeonGreen, which is brighter than GCaMP6s and performs comparably in various imaging applications.

ACS Sensors · Jun 23, 2020Peer-reviewedMolecular Biology