Ronak H. Patel

A sensitive orange fluorescent calcium ion indicator for imaging neural activity

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

Glutamate indicators with increased sensitivity and tailored deactivation rates

The paper develops two variants of a glutamate indicator with enhanced sensitivity and tailored deactivation rates for studying synaptic transmission in vivo.

Far-red fluorescent genetically encoded calcium ion indicators

This paper introduces two new far-red fluorescent GECIs, FR-GECO1a and FR-GECO1c, characterized for their Ca2+ sensitivity and performance in neuronal imaging.

iGABASnFR2: Improved genetically encoded protein sensors of GABA

The paper improves a GABA sensor, iGABASnFR2, with higher sensitivity and faster kinetics, enabling better in vivo imaging of GABAergic transmission.

Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore

This paper introduces a fluorophore for imaging extracellular matrix in live tissues and organisms by binding to glycans, enabling nonperturbative and wash-free visualization.

A modular chemigenetic calcium indicator enables in vivo functional imaging with near-infrared light

The paper introduces WHaloCaMP, a near-infrared calcium indicator, and demonstrates its use in imaging calcium responses in various organisms.

Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

This paper develops improved glutamate indicators with faster activation kinetics and better synaptic localization for imaging synaptic transmission in neurons.

Fast and sensitive GCaMP calcium indicators for imaging neural populations

The paper develops fast and sensitive GCaMP indicators for neural activity imaging, achieving ultra-fast kinetics and high sensitivity.

Brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

The paper develops DELTA, a method to measure brain-wide synaptic protein turnover at single-synapse resolution, revealing localized plasticity in hippocampal CA1 during learning.

A bright and high-performance genetically encoded Ca2+ indicator based on mNeonGreen fluorescent protein

The paper develops a new genetically encoded Ca2+ indicator, mNG-GECO1, based on mNeonGreen, which is brighter than GCaMP6s and performs comparably in various imaging applications.

jYCaMP: An optimized calcium indicator for two-photon imaging at fiber laser wavelengths

The paper introduces jYCaMP1, a calcium indicator optimized for two-photon imaging at wavelengths above 1000 nm, showing improved performance in mice and flies.

rsCaMPARI: an erasable marker of neuronal activity

The paper introduces rsCaMPARI, an erasable neuronal activity marker that allows for marking, erasing, and remarking of active neuron populations in zebrafish.

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

The paper introduces a new genetically encoded voltage indicator, Voltron, which improves brightness and photostability for extended in vivo voltage imaging in mice, zebrafish, and fruit flies.

High-performance GFP-based calcium indicators for imaging activity in neuronal populations and microcompartments

Structure-guided mutagenesis of GCaMP6 plus neuron-based screening yields a jGCaMP7 family, each variant tuned to a different regime: single spikes, neurites and neuropil, or population imaging.