PAUL S. SCHMIDT

Intragenic epistasis in couch potato shapes life history traits and climatic adaptation in Drosophila melanogaster

The paper shows non-additive interactions among three intronic SNPs in the cpo gene affect life history traits and climatic adaptation in Drosophila melanogaster.

Climate predicts wMel Wolbachia frequency variation in Drosophila melanogaster, but genomic variation reflects a recent incomplete cytoplasmic sweep

The paper shows climate factors predict wMel Wolbachia frequency globally, but genomic variation reflects a recent incomplete cytoplasmic sweep rather than local adaptation.

Seasonal evolution of Drosophila melanogaster abdominal pigmentation is associated with a multifarious selective landscape

This study shows Drosophila melanogaster pigmentation adapts to temperature, competition, diet, and microbiome, indicating a complex selective landscape.

Pervasive fitness trade-offs revealed by rapid adaptation in large experimental populations of Drosophila melanogaster

This study uses genomic data from Drosophila melanogaster to show how fitness trade-offs manifest under fluctuating selection, identifying genomic regions linked to reproduction and stress tolerance.

Multiparent Recombinant Inbred lines crossed to a tester provide novel insights into sources of cis and trans regulation of gene expression

The paper introduces a method using multi-parent RILs crossed to a tester to dissect cis and trans regulation of gene expression in Drosophila, finding environmental and genetic trans effects in 31% and 19% of loci respectively.

Ecological stoichiometry and life history theory, not the identity of genomic variants, predict rapid adaptation

This study shows ecological stoichiometry and life history theory predict phenotypic adaptation in Drosophila, while genomic data fail to predict the SNPs and genes involved.

High-resolution mapping of a rapidly evolving complex trait reveals genotype-phenotype stability and an unpredictable genetic architecture of adaptation

This study maps the genetic architecture of pigmentation evolution in Drosophila melanogaster and finds that while trait direction can be predicted, the specific loci involved are unpredictable and the genotype-phenotype map is stable across populations.

The microbiota elicits compensatory adaptation in a seasonally-adapting animal host

This study shows that microbiota influences seasonal adaptation in Drosophila by driving compensatory developmental changes across seasons and locations.

Environment and diet shape the geography-specific Drosophila melanogaster microbiota composition

This study shows that environmental factors like temperature and diet shape the microbiota composition of wild Drosophila melanogaster, linking microbiota variation to host phenotypic differentiation.

Beneficial reversal of dominance maintains a resistance polymorphism under fluctuating insecticide selection

The paper shows that beneficial reversal of dominance at the Ace locus in Drosophila melanogaster allows resistant alleles to persist under fluctuating insecticide selection.

Variation in Resource Environment Drives Adaptive Divergence in Drosophila melanogaster

This study shows that resource variation in Drosophila melanogaster affects phenotypic and genomic evolution but is secondary to seasonal selective pressures, with adaptation to resource environments being trait-specific.

Footprints of worldwide adaptation in structured populations of D. melanogaster through the expanded DEST 2.0 genomic resource

The paper uses DEST 2.0 to analyze genetic variation in D. melanogaster across continents and time, identifying adaptation patterns and stable spatial genetic structures.

Drosophila melanogaster pigmentation demonstrates adaptive phenotypic parallelism over multiple timescales

This study shows that Drosophila melanogaster pigmentation adapts rapidly and deterministically to environmental gradients across multiple timescales through distinct genetic components.

Humidity determines penetrance of a latitudinal gradient in genetic selection on the microbiota by Drosophila melanogaster

This study shows that humidity influences the genetic selection on microbiota in Drosophila melanogaster, with variation in microbiota composition linked to latitude and environmental conditions.

An epigenetic basis of adaptive plasticity in Drosophila melanogaster

This study identifies epigenetic factors underlying adaptive phenotypic plasticity in Drosophila melanogaster, showing genotype-dependent chromatin changes associated with diapause.

Drosophila Evolution over Space and Time (DEST) - A New Population Genomics Resource

The paper develops a bioinformatics pipeline to integrate Drosophila melanogaster genomic data from diverse sources, creating a large dataset called DEST for population genetics analysis.

Note: Updating the metadata of four misidentified samples in the DrosRTEC dataset

The paper updates metadata for four misidentified samples in the DrosRTEC dataset using PCA and DAPC analysis of published datasets.

Unique genetic signatures of local adaptation over space and time for diapause, an ecologically relevant complex trait, in Drosophila melanogaster

The paper identifies genetic variants associated with diapause in Drosophila melanogaster, showing spatial and temporal variation in their evolutionary patterns.

Microbiome composition shapes rapid genomic adaptation of Drosophila melanogaster

This study shows microbiome manipulation drives rapid genomic adaptation in Drosophila melanogaster by altering allele frequencies across the genome.

The microbiota influences the Drosophila melanogaster life history strategy

This study shows that microbiota in Drosophila melanogaster influences life history strategies, overriding host genetic adaptations in some cases.

An amino acid polymorphism in the Drosophila insulin receptor demonstrates pleiotropic and adaptive function in life history traits

The paper identifies an amino acid polymorphism in the Drosophila insulin receptor that shows pleiotropic effects on life history traits and adaptive variation across geographic regions.