Alan P. Koretsky

A reactivated thalamocortical plasticity window promotes learning and is reshaped by experience

The paper shows that adult mice can re-experience critical-period-like plasticity after sensory loss, which enhances learning when aligned with specific timing windows.

Manganese Accumulation for Genetically Induced Contrast (MAGIC) MRI in the brain across species

The paper introduces MAGIC MRI, a gene-based reporter system for non-invasive neural tracing in vivo, validated in rodents and rhesus macaques.

Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease

This study shows that electro-calcium uncoupling in endothelial cells precedes neurodegeneration and cognitive decline in 5xFAD mice.

Post-Critical Period Transcriptional and Physiological Adaptations of Thalamocortical Connections after Sensory Loss

This study investigates transcriptional and physiological changes in thalamocortical connections after unilateral whisker denervation, finding increased synaptic activity and gene expression related to glutamate receptors.

Age Dependent Integration of Cortical Progenitors Transplanted at the Adult CSF-Brain Interface

This study transplants rat cortical progenitors into adult rat brains to create brain-like tissues and assesses their integration and connectivity across different host ages.

Early detection of cerebrovascular pathology and protective antiviral immunity by MRI

This study uses MRI to detect early cerebrovascular pathology and track antiviral T cells in a murine model of CNS infection.

Outlier detection in multimodal MRI identifies rare individual phenotypes among 20,000 brains

This study uses unsupervised outlier detection in multimodal MRI data from 20,000 UK Biobank subjects to identify rare individual phenotypes, finding high reliability for some measures and confirming many outliers through radiological review.

Mapping the brain-wide network effects by optogenetic activation of the corpus callosum

This study uses optogenetic activation of the corpus callosum to map brain-wide network effects using fMRI and calcium recording.

High-resolution MEMRI characterizes laminar specific ascending and descending spinal cord pathways in rats

This study uses MEMRI to visualize laminar-specific spinal cord pathways in rats, showing T1 signal enhancement in specific laminae after MnCl2 administration.