Author

Maria Bottermann

Ragon Institute of MGH, MIT and HarvardORCID 0000-0002-8178-100XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Facundo D. BatistaiD· 3 shared Andrew B. WardiD· 2 shared John E. WarneriD· 2 shared Paula Maldonado VillavicencioiD· 2 shared Stephanie R. WeldoniD· 2 shared Thavaleak PrumiD· 2 shared Xiao LiuiD· 2 shared Agnes A. Walsh· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

Facundo D. BatistaORCID

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Author profile →

3 papers

Recent·Most cited

A Germinal Center-Independent Innate-Like Memory B Cell Compartment of B1 Origin

Paula Maldonado Villavicencio, Maria Bottermann, Myriam Ortiz Isuiza, Shivang Parikh, John E. Warner, Anthony Alicea, Elizabeth Zhou, Thavaleak Prum, Hannah Naili, Xiao Liu, Stephanie R. Weldon, Facundo D. Batista

The paper identifies a GC-independent memory B cell subset derived from B1 cells that contributes to protective immunity against viral infection.

bioRxiv · Jul 25, 2026 · PreprintImmunology

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryoEM

James A. Ferguson, Sai Sundar Rajan Raghavan, Garazi Peña Alzua, Disha Bhavsar, Jiachen Huang, Alesandra J. Rodriguez, Jonathan L. Torres, Maria Bottermann, Julianna Han, Florian Krammer, Facundo D. Batista, Andrew B. Ward

This paper develops a method to discover monoclonal antibodies directly from immune sera using cryoEM and computational tools, significantly speeding up the process and improving accuracy.

Science Advances · Aug 15, 2025Peer-reviewedImmunology

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization

Amrit Raj Ghosh, Rumi Habib, Nitesh Mishra, Ryan S. Roark, Madhav Akauliya, Ali A. Albowaidey, Joel D. Allen, Khaled Amereh, Gabriel Avillion, Maria Bottermann, Bo Liang, Namit Chaudhary, Sean Callaghan, Jonathan Dye, Xuduo Li, , Facundo D. Batista

This study shows that a single immunization with a germline-targeting trimer can induce broad HIV-1 neutralizing antibodies in a rhesus macaque bnAb mouse model.

bioRxiv · Jun 12, 2025 · PreprintImmunology