Author

Thavaleak Prum

Ragon Institute of MGH, MIT and HarvardORCID 0009-0004-6973-5053Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Facundo D. BatistaiD· 3 shared John E. WarneriD· 3 shared Paula Maldonado VillavicencioiD· 3 shared Stephanie R. WeldoniD· 3 shared Xiao LiuiD· 3 shared Ali A. AlbowaideyiD· 2 shared Anthony Alicea· 2 shared Hannah Naili· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Facundo D. BatistaORCID

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Author profile →

3 papers

Recent·Most cited

A Germinal Center-Independent Innate-Like Memory B Cell Compartment of B1 Origin

Paula Maldonado Villavicencio, Maria Bottermann, Myriam Ortiz Isuiza, Shivang Parikh, John E. Warner, Anthony Alicea, Elizabeth Zhou, Thavaleak Prum, Hannah Naili, Xiao Liu, Stephanie R. Weldon, Facundo D. Batista

The paper identifies a GC-independent memory B cell subset derived from B1 cells that contributes to protective immunity against viral infection.

bioRxiv · Jul 25, 2026 · PreprintImmunology

Antibody feedback establishes an affinity brake in the germinal center

Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel L. V. Bader, Ryan H. Lim, Krystal M. Ma, Christopher A. Cottrell, Jon M. Steichen, Liling Xu, Paula Maldonado Villavicencio, Madhav Akauliya, Ja‐Hyun Koo, Jacqueline Ming Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, , Facundo D. Batista

The paper investigates how B cell affinity affects germinal center (GC) responses by showing high-affinity B cells have shorter GC residence times and lower-affinity B cells are maintained, suggesting an antibody feedback mechanism that modulates affinity and epitope spreading.

bioRxiv · Nov 13, 2025 · PreprintImmunology

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization

Amrit Raj Ghosh, Rumi Habib, Nitesh Mishra, Ryan S. Roark, Madhav Akauliya, Ali A. Albowaidey, Joel D. Allen, Khaled Amereh, Gabriel Avillion, Maria Bottermann, Bo Liang, Namit Chaudhary, Sean Callaghan, Jonathan Dye, Xuduo Li, , Facundo D. Batista

This study shows that a single immunization with a germline-targeting trimer can induce broad HIV-1 neutralizing antibodies in a rhesus macaque bnAb mouse model.

bioRxiv · Jun 12, 2025 · PreprintImmunology