Tanja Kuhlmann

Single-cell transcriptomic changes in oligodendroglial lineage cells derived from Parkinson's disease patient-iPSCs with LRRK2-G2019S mutation

The paper investigates transcriptomic changes in oligodendroglial lineage cells from PD patient-iPSCs with LRRK2-G2019S mutation, identifying altered pathways and signaling in OPCs and ODCs.

Development of a Humanized Mouse Model for Studying adult Spinal Cord myelination, remyelination and Drug Efficacy

This paper develops a humanized mouse model to study human oligodendrocyte maturation, remyelination, and drug efficacy in spinal cord injury.

The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

Glia-enriched stem-cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis

This study develops a glia-enriched 3D brain model from human iPSCs that mimics MS-related neurodegenerative phenotypes and intercellular communication.

Astrocyte-Oligodendrocyte interaction regulates central nervous system regeneration

The paper shows that astrocyte-oligodendrocyte interaction is critical for remyelination and identifies a drug strategy targeting this interaction to promote central nervous system regeneration.

The nuclear receptor NR4A1 restrains neutrophil granulocyte mediated brain damage in cerebral ischemia

This study shows NR4A1 reduces brain damage after ischemic stroke by limiting neutrophil activation and recruitment, with Cytosporone-B improving outcomes.

SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation

The paper identifies SKAP2 as a regulator of oligodendroglial migration and myelin sheath formation by analyzing differences between spinal cord and brain OPC.

Neural precursor cells contribute to decision-making by tuning striatal connectivity via secretion of IGFBPL-1

This study identifies a non-neurogenic role of SVZ-eNPCs in regulating striatal GABAergic transmission and decision-making through IGFBPL-1 secretion.

Beneficial contribution of iPSC-progeny to connexin 47 dynamics during demyelination-remyelination

The paper investigates how iPSC-derived neural progeny affect connexin 47 dynamics during demyelination and remyelination, showing their role in panglial network reconstruction.

Multiple sclerosis iPSC-derived oligodendroglia conserve their intrinsic properties to functionally interact with axons and glia in vivo

The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.