Author

Bruno Dumas

Sanofi (France)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1 Organism:yeast· 1

Frequent Co-Authors

Guy‐Franck RichardiD· 2 shared Lucie PoggiiD· 2 shared Stéphane Descorps-DeclèreiD· 2 shared Arnaud F. KleiniD· 1 shared David Viterbo· 1 shared Denis FurlingiD· 1 shared Geneviève GourdoniD· 1 shared Laureline Bétemps· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenomics

Guy‐Franck RichardORCID

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2 papers

Recent·Most cited

TALEN-induced contraction of CTG trinucleotide repeats in myotonic dystrophy type 1 cells

Laureline Bétemps, Stéphane Descorps-Declère, Olivia Frenoy, Lucie Poggi, Valentine Mosbach, Stéphanie Tomé, David Viterbo, Arnaud F. Klein, Laurence Ma, Sonia Lameiras, Thomas Cokelaer, Marc Monot, Bruno Dumas, Geneviève Gourdon, Denis Furling, Guy‐Franck Richard

This study uses TALENs to contract CTG repeats in DM1 cells, achieving 68% contraction with a recoded TALEN, while SaCas9 failed, and identifies potential off-target effects.

bioRxiv · Oct 14, 2023 · PreprintGenomics

Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations

Lucie Poggi, Lisa Emmenegger, Stéphane Descorps‐Declère, Bruno Dumas, Guy‐Franck Richard

The paper evaluates the efficacy of CRISPR-Cas nucleases on microsatellites linked to human disorders, identifying variations in cleavage efficiency and off-target mutations.

Nucleic Acids Research · Jul 6, 2021Peer-reviewedGenetics